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Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo
Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 533-541 doi: 10.1007/s11684-020-0786-5
Keywords: coronavirus disease 2019 (COVID-19) SARS-CoV-2 neurological manifestations neuroinvasion brain
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 651-658 doi: 10.1007/s11684-021-0859-0
Keywords: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 192-195 doi: 10.1007/s11684-007-0036-0
The development and benefits of metformin in various diseases
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 388-431 doi: 10.1007/s11684-023-0998-6
Keywords: metformin metabolism cancer aging neurological disorder
Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
Keywords: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 776-785 doi: 10.1007/s11684-020-0820-7
Keywords: coronavirus disease 2019 pediatrics emergency retrospective investigation severe acute respiratory syndrome coronavirus 2
Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review
Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen
Engineering 2020, Volume 6, Issue 4, Pages 415-423 doi: 10.1016/j.eng.2019.07.026
Keywords: Gut microbiota Gut–brain axis Neurological disorders Intervention strategies
Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through
Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik
Engineering 2021, Volume 7, Issue 2, Pages 141-143 doi: 10.1016/j.eng.2020.06.020
Title Author Date Type Operation
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from
Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo
Journal Article
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
Journal Article
Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
Journal Article
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral
Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG
Journal Article
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
Journal Article
Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders
Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen
Journal Article